House and the team take on the case of a woman who collapsed in the middle of a cooking class. When they learn that the patient gave up her career as a highly renowned cancer researcher in order to pursue her own personal happiness, the members of the team question their own happiness (or lack thereof). Meanwhile, Thirteen begins to suffer serious and life-threatening reactions to her experimental Huntington's Disease clinical drug trial, and Cuddy retaliates against House and gives him a taste of his own medicine.
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