Reilly's Talledega Nights co-star Will Ferrell made a cameo appearance as James Lipton during Reilly's monologue.
This episode was the first live episode to feature the logo that would be used for the rest of season 32 onward, though the repeat of the Dane Cook/The Killers episode the previous week was the first show ever to feature the new, third logo revision.
My Chemical Romance performed "Welcome to the Black Parade" and "Cancer".
The Village Voice extensively covered the backstage preparation for the week leading up to this episode.
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