Billionaire entrepreneur Edward Vogler donates $100 million to Princeton-Plainsboro, officially becoming the new Chairman of the Board. Vogler intends to turn the clinic into a profitable venue for his biotech venture and also plans to eliminate House's financially draining department for good. Meanwhile, a businesswoman has it all – perfect life, perfect body, perfect job – until she finds herself inexplicably paralyzed. When he diagnoses her condition, House must risk his job and his medical license to save her.
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