When House and his team are working on the diagnosis of a man with a swollen tongue, the husband of a former patient walks into House's office and promptly shoots him. House continues to treat his patient from his ICU bed although the shooter (Elias Koteas), who was shot by hospital security and handcuffed to his bed, has become his roommate. When the after effects of the shooting begin to impact House, he starts to question his own ability to diagnose properly. As his patient's body deteriorates, House struggles through self-doubt and must trust his team to find a way to solve the case as well as trying to divide reality from fiction.
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