While looking for their father who has disappeared, demon hunters Sam and Dean start to investigate a bizarre string of murders in which husbands are being accused of killing their wives. The brothers head to a town in Missouri. While the suspects are the husbands and there's evidence that supports that they did it, all of them insist that they are innocent. Sam and Dean think that it might be the doing of their ikiryou (from Japanese mythology - a vengeful manifestation of part of a living person's soul) and start the investigation, however...
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