Gary Lineker presents highlights from the day's eight Premier League games, with studio guests Alan Hansen and Alan Shearer.
Newcastle host Liverpool at St James' Park. Alan Pardew's side will be keen to avenge the 6-0 thrashing they suffered against the Reds in April, a result which was the Magpies' biggest home loss since 1925.
Manchester United face a potentially tricky match at home to a Southampton side who strengthened heavily this summer, spending over £30m on the signings of Dani Osvaldo, Victor Wanyama and Dejan Lovren.
Elsewhere, Arsenal host Norwich, Chelsea meet Cardiff and West Ham take on Manchester City. Struggling Sunderland head to Swansea desperate for points, while Everton meet Hull and Stoke play West Brom.
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