House takes the case of Adam, a 10-year-old severely autistic boy, who screams loudly for no apparent reason. Cuddy makes a minor change to House's office and he refuses to use it until it is returned to its original state; thus, he finds himself wandering the hospital in need of a temporary office. Meanwhile, the teenage clinic patient (Leighton Meester) still has a crush on House and is becoming a nuisance.
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