The setting of the story is a fictional world of abundant towns where humans coexist with demons called Yoma. These monsters feed on humans as their main source of food, hiding themselves in human society until they strike.
A group of skilled warriors form a nameless organization to protect humans from these demons. These warriors are called Claymores, after their immense Claymore weapons. They willingly infuse themselves with demon flesh and blood to become powerful half-human hybrids. Villages in danger of attack hire warriors from the organisation for protection.
The story of Claymore follows the adventures of the beautiful Claymore warrior Clare, who fights demons and struggles to hold on to her humanity.
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